A new tool enables biomedical researchers from around the world to quickly see the connections between lipids and proteins inside cells, thanks to a new initiative led by scientists at Oregon Health & ...

Integrating AI with advanced robotics to create self-driving labs (SDL) is a promising approach to tackling molecular ...

To create A1 lipid nanoparticles for delivering mRNA to target cells, scientists at the University of Pennsylvania used A3 coupling. A3 refers to the amine–aldehyde–alkyne coupling reaction, which the ...

Just as a chef perfects a dish by experimenting with flavors and textures, the researchers used an iterative process, testing variations to find the ideal structure for the ionizable lipid. This lipid ...

Penn Engineers have cooked up a new way to improve mRNA delivery, developing an optimal “recipe” for ionizable lipids — key ingredients in lipid nanoparticles (LNPs), the molecules behind the COVID-19 ...

Scientists have developed a method for analysing the structure of lipid nanoparticles that could be used to improve vaccine and drug delivery, targeting a wide range of health issues. A team led by ...

Penn Engineers have cooked up a new way to improve mRNA delivery, developing an optimal "recipe" for ionizable lipids - key ingredients in lipid nanoparticles (LNPs), the molecules behind the COVID-19 ...

New research finds that sleep is essential for protecting brain mitochondria by transferring toxic metabolic waste from neurons to glial cells for disposal.

A long-standing mystery in bile acid biology has been solved. Bile acids are often introduced as digestion helpers, but they are also powerful chemical messengers that help coordinate metabolism ...

Penn Engineers have cooked up a new way to improve mRNA delivery, developing an optimal "recipe" for ionizable lipids—key ingredients in lipid nanoparticles (LNPs), the molecules behind the COVID-19 ...