Cells constantly monitor and recycle their proteins through a tightly regulated waste-disposal system. Proteins that are no ...

Molecular glues are enjoying the spotlight, but discovering new ones is often a matter of luck. A new method, developed by ...

A new active substance attacks a key protein in tumor cells, leading to complete degradation. In cell experiments, this caused cancer cells to lose their protection and die. The active substance was ...

Age-related changes in protein tagging and degradation may help explain how the brain declines over time and why diet can still influence these processes.

Edited by: Thomas W. Durso and Karen Young Kreeger M. Hochstrasser, "Ubiquitin, proteasomes, and the regulation of intracellular protein degradation," Current Opinion in Cell Biology, 7:215-23, 1995. ...

In this Teach Me in 10, Dr. Sam Jensen provides a comprehensive overview of the tools, assays and strategies needed at each ...

Origami is collaborating with Ipsen to develop molecules designed to remove or correct abnormal proteins in neurodegenerative diseases.

Carfilzomib prevented BCMA degradation, increased target density, and improved CAR T susceptibility by ~26%–28% in vitro, while enhancing xenograft antitumor activity without worsening T-cell ...

Drug resistance continues to limit the long-term benefit of many targeted therapies and chemotherapies against cancer. While “classical” small-molecule ...